Insomnia

​

A literature review that indicates CBD has therapeutic potential for the treatment of insomnia, REM sleep behavior disorder, excessive daytime sleepiness and reduction of nightmares associated with PTSD.

Babson, K., Sottile, J and Morabita D. Cannabis, cannabinoids and Sleep:  a Review of the Literature.  Current Psychiatry Reports, [online] 19(4).  2017.

https://www.ncbi.nlm.nih.gov/pubmed/28349316

 

Depression

​

This study reviews animal models using CBD as an anti-depressant-like compound.  Most studies showed a positive interaction between CBD and the 5-HT1A neuro-receptor.  Activation of the 5-HT1A neuro-receptor is know to be involved in the mechanism of action of antidepressant and antipsychotic medications. 

Schier, A., Ribeiro, N., Coutinho, D., Machado, S., Arias-Carrion, O., Crippa, J., Zuardi, A., Nardi, A and Silva, A.  Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol:  A Chemical Compound of Cannabis sativa.  CNS & Neurolocgical Disorders- Drug Targets, [onlin] 13(6), pp. 953-960,  2014.

https://www.ncbi.nlm.nih.gov/pubmed/24923339

 

Osteoporosis

​

Several reports on CBD receptors identify the potential for use of CBD to combat osteoporosis. 

Bab, I., Zimmer, A. and Melamed, E.  Cannabinoids and the skeleton:  From marijuana to the reversal of boneloss.  Annals of Medicine, [online] 41(8).  2009.

https://www.ncbi.nlm.nih.gov/pubmed/19634029

 

Chronic Inflammation/Chronic Pain

​

Cannabinoid analgesics have demonstrated to be promising for the treatment of pain. 

Russo, E.  Cannabinoids in the management of difficult to treat pain.  Therapeutics and Clinical Risk Management, [online] Volume 4.  2008

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/

 

CBD found to be effective in suppression of chronic inflammatory and neuropathic pain.

Wei Xiong et al.  Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors, Journal of Experimental Medicine.  May 14, 2012.

http://jem.rupress.org/content/209/6/1121

 

Pets

​

CBD effective in reducing pain and increasing activity in dogs with osteoarthritis.

Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs.  Gamble, L.J. et al.  Frontiers in Veterinary Science, 23 July 2018.

https://www.frontiersin.org/articles/10.3389/fvets.2018.00165/full

 

Pediatrics

​

Study looked at the efficacy, safety and tolerability of medical cannabis in children with complex motor disorder.  Significant improvement was found in pain severity, sleep difficulties, continual spasm, and uncontrollable muscle contraction.

Medical Cannabis for Pediatric Moderate to Severe Complex Motor Disorders.  Libzon, S. et al.  Journal of Child Neurology, Vol 33, Issue 9, May 16, 2018.

https://doi.org/10.1177/0883073818773028

 

Epilepsy

 

Study of the efficacy of CBD in addition to the epilepsy pharmaceutical clobazam in the treatment of epilepsy.  The study found that the additional of CBD resulted in 39% of patients having a more than 50% reduction in seizures, with 10% becoming seizure free.   Weaning of antiepileptic drugs became possible in 22% of students. 

Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy:  Practical experiences in a tertiary medical center.  Epilepsy and Behavior, Vol 80 pp. 240-246, March 2018.

https://doi.org/10.1016/j.yebeh.2018.01.026

 

In a study of 74 children with epilepsy, CBD treatment yielded a significant positive effect on reducing seizures.   89% of patients reported some reduction in seizure frequency, and 18% had 75-100% reduction. 

CBD-enriched medical cannabis for intractable pediatric epilepsy.  Seizure, European Journal of Epilepsy.  Volume 35, pp. 41-44.  February 2016.

https://doi.org/10.1016/j.seizure.2016.01.004

 

Dermatology

​

A review of studies about cannabinoids and dermatology show promise for the treatment of skin conditions such as extreme dry skin caused by ageing or diabetes (xerosis or pruritis). 

Jessica S. Mounessa, Julia A. Siegel, Cory A. Dunnick, Robert P. Dellavalle. The role of cannabinoids in dermatology. Journal of the American Academy of Dermatology, 2017; DOI: 10.1016/j.jaad.2017.02.056 https://www.jaad.org/article/S0190-9622(17)30308-0/fulltext

 

 

Topical medical cannabis used to treat patients with the skin disorder, Pyoderma gangrenosum.  The study reports clinically significant analgesia and the potential to improve pain management in patients with the use of topical cannabis. 

Topical Medical Cannabis:  A New Treatment for Wound Pain- Three Cases of Pyroderma Gangrenosum.  Maida, V. MD, MSc, BSc, and J. Corban, MD, CM, Hon BSc.  Journal of Pain and Symptom Management, Vol 54, Issue 5, pp. 732-736.  November 2017.

 https://doi.org/10.1016/j.jpainsymman.2017.06.005

 

Study investigates and validates the use of CBD as a potential therapeutic agent for the treatment of acne. 

Cannadbidiol exerts sebostatic and antiinflammatory effects on human sebocytes.  Journal of Clinical Investigation.  2014 Sep 2; 124(9): 3713-3724.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151231/

 

Irritable Bowel Disease (IBD)

 

CBD given to patients with Irritable Bowel Disease was helpful in decreasing inflammation.  The paper found a scientific basis for supporting the clinical development of CBD in IBD treatment.

An Orally Active Cannabis Extract with High Content in Cannabidiol attenuates Chemically-induced Intestinal Inflammation and Hypermotility in the Mouse.  Frontiers in Pharmacology, 04 October 2016.

https://doi.org/10.3389/fphar.2016.00341

 

Study looked at the effect of CBD use by a patient with bipolar disease and marijuana addiction.  CBD oil was effective in decreasing anxiety, increasing sleep and improving interactions with family members. 

Cannabidiol Oil for Decreasing Addictive Use of Marijuana:  A Case Report.  Integrated Medicine:  A Clinician's Journal. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718203/

 

Arthritis

 

Study found that topical CBD application has the therapeutic potential for relief of arthritis pain-related behaviors and inflammation without evident side-effects.

Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis.  European Journal of Pain.  2016 Jul; 20(6): 936-948.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851925/